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hanska rx-5 in a pickle you must to control system by smarajit ghosh pdf 85The term “complement system” refers to a complex group of proteins that function together in immune and inflammatory response to infection. In this regard, the complement system participates in both the innate immune response to microbial pathogens and the adaptive immune response to antigens.
The complement system has three pathways by which it can act to amplify and/or initiate the immune response. All three pathways involve activation of serine proteases (e.g., C1r, C1s, C2, C4, C3 and properdin) that act to cleave complement component proteins.
The classical pathway is characterized by formation of a complex of C1r, C1s and C1q, which promotes the assembly of C4 and C2 to C4b and C2b, respectively. This complex, in turn, promotes the formation of the C3 convertase, C4b, C2b, C3b. The cascade can be propagated via the alternative pathway (e.g., by the action of factor B), or the mannose-binding lectin (e.g., by the action of factor D) pathway.
In the alternative pathway, assembly of properdin, factor B and factor D leads to activation of the serine protease C3. In the resulting C3 convertase (C4b, C2a, C3b), the complex becomes a positive feedback amplifier of the activation pathway.
In addition to the C3 convertase, each of the three pathways can produce cleavage of C5 into C5a and C5b. Cleavage of C5a and 0b46394aab
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